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Year : 1993  |  Volume : 41  |  Issue : 2  |  Page : 105--108

Tri-o-cresyl phosphate induced neuropathy : pathological study of human sural nerve biopsy

Department of Neurology, Government Rajaji Hospital, Madurai, India

Correspondence Address:
K Srinivasan
Department of Neurology, Government Rajaji Hospital, Madurai
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Source of Support: None, Conflict of Interest: None

PMID: 29542499

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An 18 year old male who consumed food cooked in contaminated cooking oil, during an epidemic at Calcutta in 1988, developed Tri-O-Cresyl Phosphate toxicity and peripheral neuropathy. Pathological study revealed focal loss of large myelinated fibres.EM study showed accumulation of agranular reticulum in relatively preserved axons and axonal and myelin vacuolation and accumulation of dark bodies and granular transformation of axoplasm in more affected axons, similar to those described in experimentalanimals.

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Online since 20th March '04
Published by Wolters Kluwer - Medknow