Neurology India
Open access journal indexed with Index Medicus
  Users online: 1586  
 Home | Login 
  About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe Etcetera Contact  
  Navigate Here 
 ╗   Next article
 ╗   Previous article
 ╗   Table of Contents

 Resource Links
 ╗   Similar in PUBMED
 ╗  Search Pubmed for
 ╗  Search in Google Scholar for
 ╗Related articles
 ╗   Citation Manager
 ╗   Access Statistics
 ╗   Reader Comments
 ╗   Email Alert *
 ╗   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed31041    
    Printed855    
    Emailed68    
    PDF Downloaded1168    
    Comments [Add]    
    Cited by others 30    

Recommend this journal

 

 REVIEW ARTICLE
Year : 2004  |  Volume : 52  |  Issue : 3  |  Page : 310--318

Vitamin B12 and folate depletion in cognition: A review


1 Dipartimento Fisiologia e Patologia, UniversitÓ degli Studi, Trieste, Italy
2 Dipartimento Medicina Clinica e Neurologia, UCO Clinica Neurologica, UniversitÓ degli Studi, Trieste, Italy

Correspondence Address:
Rita Moretti
Dipartimento Fisiologia e Patologia, UniversitÓ degli Studi, Trieste
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 15472418

Rights and PermissionsRights and Permissions

In cross-sectional studies, low levels of folate and B12 have been shown to be associated with cognitive decline and dementia Evidence for the putative role of folate, vitamin B12 in neurocognitive and other neurological functions comes from reported cases of severe vitamin deficiencies, particularly pernicious anemia, and homozygous defects in genes that encode for enzymes of one-carbon metabolism. The neurological alterations seen in these cases allow for a biological role of vitamins in neurophysiology. Results are quite controversial and there is an open debate in literature, considering that the potential and differential role of folate and B12 vitamin in memory acquisition and cognitive development is not completely understood or accepted. What is not clear is the fact that vitamin B12 and folate deficiency deteriorate a pre-existing not overt pathological situation or can be dangerous even in normal subjects. Even more intriguing is the interaction between B12 and folate, and their role in developing hyperhomocysteinemia. The approach to the rehabilitation of the deficiency with adequate vitamin supplementation is very confusing. Some authors suggest it, even in chronic situations, others deny any possible role. Starting from these quite confusing perspectives, the aim of this review is to report and categorize the data obtained from the literature. Despite the plausible biochemical mechanism, further studies, based on clinical, neuropsychological, laboratory and (lastly) pathological features will be necessary to better understand this fascinating biochemical riddle.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow