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 REVIEW ARTICLE
Year : 2003  |  Volume : 51  |  Issue : 4  |  Page : 455--460

Botulinum toxins: Pharmacology and its current therapeutic evidence for use


Department of Neurology NIMHANS Hosur Road, Bangalore - 560029, India

Correspondence Address:
U B Muthane
Department of Neurology NIMHANS Hosur Road, Bangalore - 560029
India
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Source of Support: None, Conflict of Interest: None


PMID: 14742921

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Botulinum toxins are, as a group, among the most potent neuromuscular toxins known, yet they are clinically useful in the management of conditions associated with muscular and glandular over-activity. Botulinum toxins act by preventing release of acetylcholine into the neuromuscular junction. While botulinum toxin type A is commonly available, different manufacturers produce specific products, which are not directly interchangeable and should not be considered as generically equivalent formulations. Type B is also available in the market. Each formulation of botulinum toxin is unique with distinct dosing, efficacy and safety profiles for each use to which it is applied. Botulinum toxin type A is the treatment of choice based on its depth of evidence in dystonias and most other conditions. Botulinum toxin type A is established as useful in the management of spasticity, tremors, headache prophylaxis and several other neurological conditions. Active research is underway to determine the parameters for which the type B toxin can be used in these conditions, as covered in this review. Botulinum toxin use has spread to several fields of medicine.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow